Department of Biology
Investigation of N-methyl-D-aspartate induced mechanical behavior of neuroblastoma cells using atomic force microscopy
Physiological conditions of biological samples are regulated by many different parameters including mechanical and biochemical factors etc. Single-cell studies of these parameters are challenging by using conventional bioanalysis methods. However, with the recent advancement in nanotechnology, single-molecule and single-cell analysis is much more accessible. Understanding the changes of neuroblastoma cells in different mechanisms is critical for fundamental research in neurosciences. Here, we investigate the mechanical behavior of SH-SY5Y cells using atomic force microscopy. Topographic imaging of the cells and real-time quantitative analysis of their mechanical properties will be presented in the paper. © 2013 IEEE.
Source Publication Title
Proceedings of the 13th IEEE International Conference on Nanotechnology
Link to Publisher's Edition
Fang, Yuqiang, King W. C. Lai, Catherine Y. Y. Iu, Cathy N. P. Lui, Carmen K. M. Fung, Hung-Wing Li, Ken K. L. Yung, and Ning Xi. "Investigation of N-methyl-D-aspartate induced mechanical behavior of neuroblastoma cells using atomic force microscopy." Proceedings of the 13th IEEE International Conference on Nanotechnology (2013): 329-332.