School of Chinese Medicine
Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.
Source Publication Title
Organic and Biomolecular Chemistry
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2012
This research is funded by The Science and Technology Department of Guiyang [No. (2008) 36].
Link to Publisher's Edition
Zou, Juan, Lutai Pan, Qiji Li, Jianxin Pu, Ping Yao, Min Zhu, Jeffrey A. Banas, Hongjie Zhang, and Handong Sun. "Rubesanolides C–E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity." Organic and Biomolecular Chemistry 10.26 (2012): 5039-5044.
Additional FilesJA-5193-26008_suppl.txt (71 kB)
Crystal structure data