School of Chinese Medicine
Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.
Source Publication Title
Organic and Biomolecular Chemistry
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2012
This research is funded by The Science and Technology Department of Guiyang [No. (2008) 36].
Link to Publisher's Edition
Zou, J., Pan, L., Li, Q., Pu, J., Yao, P., Zhu, M., Banas, J., Zhang, H., & Sun, H. (2012). Rubesanolides C–E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity. Organic and Biomolecular Chemistry, 10 (26), 5039-5044. https://doi.org/10.1039/C2OB25192B
Additional FilesJA-5193-26008_suppl.txt (71 kB)
Crystal structure data