Department of Chemistry
Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus
A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes. © 2014 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Lam, P., Lu, G., Hon, K., Lee, K., Ho, C., Wang, X., Tang, J., Lam, K., Wong, R., Kok, S., Bian, Z., Li, H., Lee, K., Gambari, R., Chui, C., & Wong, W. (2014). Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus. Dalton Transactions, 43 (10), 3949-3957. https://doi.org/10.1039/c3dt52879k