Document Type

Journal Article

Authors

P. L. Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
G. L. Lu, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist University
K. M. Hon, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist University
K. W. Lee, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist University
C. L. Ho, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist UniversityFollow
X. Wang, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist University
J. C O Tang, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
K. H. Lam, State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University
R. S M Wong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
S. H L Kok, School of Biomedical Sciences, Chinese University of Hong Kong
Z. X. Bian, Clinical Division, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
H. Li, College of Life and Environmental Sciences, Minzu University of China
K. K H Lee, School of Biomedical Sciences, Chinese University of Hong Kong
R. Gambari, Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara
C. H. Chui, Clinical Division, School of Chinese Medicine, Hong Kong Baptist UniversityFollow
W. Y. Wong, Department of Chemistry, Institute of Advanced Materials, Hong Kong Baptist UniversityFollow

Department/Unit

Department of Chemistry

Title

Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Language

English

Abstract

A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes. © 2014 The Royal Society of Chemistry.

Publication Date

2014

Source Publication Title

Dalton Transactions

Volume

43

Issue

10

Start Page

3949

End Page

3957

Publisher

Royal Society of Chemistry

DOI

10.1039/c3dt52879k

Link to Publisher's Edition

http://dx.doi.org/10.1039/c3dt52879k

ISSN (print)

14779226

ISSN (electronic)

14779234

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