Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus
Language
English
Abstract
A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes. © 2014 The Royal Society of Chemistry.
Publication Date
2014
Source Publication Title
Dalton Transactions
Volume
43
Issue
10
Start Page
3949
End Page
3957
Publisher
Royal Society of Chemistry
DOI
10.1039/c3dt52879k
Link to Publisher's Edition
ISSN (print)
14779226
ISSN (electronic)
14779234
Recommended Citation
Lam, P. L., G. L. Lu, K. M. Hon, K. W. Lee, C. L. Ho, X. Wang, J. C O Tang, K. H. Lam, R. S M Wong, S. H L Kok, Z. X. Bian, H. Li, K. K H Lee, R. Gambari, C. H. Chui, and W. Y. Wong. "Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus." Dalton Transactions 43.10 (2014): 3949-3957.