School of Chinese Medicine
Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus. © 2013 Elsevier Ltd. All rights reserved.
Antibacterial agents, Antibiotics, Quinolines, Staphylococcus aureus
Source Publication Title
Bioorganic and Medicinal Chemistry Letters
Link to Publisher's Edition
Lam, K., Gambari, R., Lee, K., Chen, Y., Kok, S., Wong, R., Lau, F., Cheng, C., Wong, W., Bian, Z., Chan, A., Tang, J., & Chui, C. (2014). Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus. Bioorganic and Medicinal Chemistry Letters, 24 (1), 367-370. https://doi.org/10.1016/j.bmcl.2013.10.072