Document Type

Journal Article

Department/Unit

School of Chinese Medicine; Department of Biology

Title

The melanogenesis-inhibitory effect and the percutaneous formulation of ginsenoside Rb1

Language

English

Abstract

Ginsenoside Rb1 (Rb1) is the most predominant ginsenoside isolated from the roots of ginseng (Panax ginseng C. A. Meyer). This compound is active in various human biological pathways that are involved in human collagen synthesis and inhibition of cell apoptosis. In this study, the skin-whitening effects of Rb1 were investigated in B16 melanoma cells. Our results showed that Rb1 inhibited melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 cells in a dose-dependent manner, which collectively indicated that Rb1 may have skin-whitening effects and may be formulated into skin-whitening products for skin care. Accordingly, a ginsenoside collagen transdermal patch was developed as a vehicle to topically deliver Rb1 into pig skin. The percutaneous permeation, retention within skin, and release in vitro of Rb1 from seven transdermal patch formulas were studied. It was determined that the best formula for ginsenoside collagen transdermal patch is made of protein collagen hydrolysate powder (PCHP) 2.0% (w/w), methyl cellulose (MC) 0.5% (w/w), polyethyleneglycol 6000 (PEG6000) 0.5% (w/w), ginsenoside 0.036% (w/w), azone 0.4% (v/w), menthol 0.20% (w/w), and water.

Keywords

ginsenoside rb1, melanin, permeation, skin whitening, transdermal patch

Publication Date

10-2014

Source Publication Title

AAPS PharmSciTech

Volume

15

Issue

5

Start Page

1252

End Page

1262

Publisher

Springer Verlag

Peer Reviewed

1

Copyright

© American Association of Pharmaceutical Scientists 2014

Funder

This work was supported by Jiangsu Overseas Research and Training Program for University Prominent Young and Middle-aged Teachers and Presidents sponsored by Jiangsu Provincial Department of Education, and also by Hong Kong Baptist University FRG2/08-09/089.

DOI

10.1208/s12249-014-0138-3

Link to Publisher's Edition

http://dx.doi.org/10.1208/s12249-014-0138-3

ISSN (electronic)

15309932

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