School of Chinese Medicine
Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities
© 2014 Springer Science+Business Media New York. A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.
8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger
Source Publication Title
Medicinal Chemistry Research
Link to Publisher's Edition
Chung, P., Gambari, R., Chen, Y., Cheng, C., Bian, Z., Chan, A., Tang, J., Leung, P., Chui, C., & Lam, K. (2015). Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities. Medicinal Chemistry Research, 24 (4), 1568-1577. https://doi.org/10.1007/s00044-014-1217-4