Department of Chemistry; Department of Biology
A colorimetric and ratiometric fluorescent pH probe with a pKa value of 6.0 based on a ring opening/closing approach of N,O-disubstituted hemiaminal ether has been developed. The probe exhibits fast response toward pH change with high selectivity and low cytotoxicity and was applied in HK-1 cells to visualize pH change.
Source Publication Title
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2015
Link to Publisher's Edition
You, Q., Lee, Y., Chan, W., Mak, N., Lee, A., Hau, S., & Mak, T. (2015). A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change. RSC Advances, 5 (6), 4099-4102. https://doi.org/10.1039/c4ra13445a