Department of Chemistry
A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm
A new carbazole-derived dicationic compound, namely 2,7-bis(1-hydroxyethyl- 4-vinylpyridinium iodine)-N-ethylcarbazole (2,7-9E-BHVC), with a large two-photon action absorption cross section in nucleic acids has been obtained. Moreover, it possesses the potential of imaging RNA in nucleoli and cytoplasm in two-photon fluorescence microscopy and exhibits good counterstain compatibility with the commercial fluorescent nucleic dye DAPI. © 2011 The Royal Society of Chemistry.
Source Publication Title
Organic and Biomolecular Chemistry
Royal Society of Chemistry
Link to Publisher's Edition
Liu, X., Sun, Y., Zhang, Y., Miao, F., Wang, G., Zhao, H., Yu, X., Liu, H., & Wong, W. (2011). A 2,7-carbazole-based dicationic salt for fluorescence detection of nucleic acids and two-photon fluorescence imaging of RNA in nucleoli and cytoplasm. Organic and Biomolecular Chemistry, 9 (10), 3615-3618. https://doi.org/10.1039/C1OB05123G