Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Antitumor activity of diethynylfluorene derivatives of gold(I)
Language
English
Abstract
A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney. © 2009 Elsevier Ltd. All rights reserved.
Keywords
Alkynes, Fluorenes derivatives, Gold(I) complexes, Human carcinoma cells, Nude mice model, Reactive oxygen species
Publication Date
2012
Source Publication Title
Bioorganic & Medicinal Chemistry
Volume
17
Issue
23
Start Page
7872
End Page
7877
Publisher
Elsevier
DOI
10.1016/j.bmc.2009.10.034
Link to Publisher's Edition
http://dx.doi.org/10.1016/j.bmc.2009.10.034
ISSN (print)
09680896
ISSN (electronic)
14643391
Recommended Citation
Chui, Chung-Hin, Raymond Siu-Ming Wong, Roberto Gambari, Gregory Yin-Ming Cheng, Marcus Chun-Wah Yuen, Kit-Wah Chan, See-Wai Tong, Fung-Yi Lau, Paul Bo-San Lai, Kim-Hung Lam, Cheuk-Lam Ho, Chi-Wai Kan, Kelvin Sze-Yin Leung, and Wai-Yeung Wong. "Antitumor activity of diethynylfluorene derivatives of gold(I)." Bioorganic & Medicinal Chemistry 17.23 (2012): 7872-7877.