Department of Chemistry
Design and synthesis of binuclear Co-salen catalysts for the hydrolytic kinetic resolution of epoxides
© 2015 Published by Elsevier B.V. Three binuclear Co(III)-salen complexes have been synthesized based on a series of hydrophilic cyclic frameworks with different ring sizes. The catalytic performance of Co-salen complexes have further been evaluated in the hydrolytic kinetic resolution of racemic epoxides. And kinetic studies reveal that the binuclear Co-salen catalysts show a higher reactivity and better enantioselectivity in comparison to monometallic reference complex, indicating the two Co-salen units on the cyclic framework may work in a cooperative manner. Specifically, Co3, with the most flexible cyclic framework exhibits the best catalytic performance among the three catalysts, due to the efficient cooperative interactions between two cobalt centers.
Asymmetric catalysis, Cobalt, Kinetic resolution, Ring-opening, Salen ligands
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Wu, F., Wang, K., Li, Z., & Zhu, X. (2015). Design and synthesis of binuclear Co-salen catalysts for the hydrolytic kinetic resolution of epoxides. Catalysis Communications, 68, 101-104. https://doi.org/10.1016/j.catcom.2015.05.006