School of Chinese Medicine; Department of Mathematics
Schisandrin B (SchB) is one of the most abundant bioactive dibenzocyclooctadiene derivatives found in the fruit of Schisandra chinensis. Here, we investigated the potential therapeutic effects of SchB on non-alcoholic fatty-liver disease (NAFLD). In lipidomic study, ingenuity pathway analysis highlighted palmitate biosynthesis metabolic pathway in the liver samples of SchB-treated high-fat-diet-fed mice. Further experiments showed that the SchB treatment reduced expression and activity of fatty acid synthase, expressions of hepatic mature sterol regulatory element binding protein-1 and tumor necrosis factor-α, and hepatic level of palmitic acid which is known to promote progression of steatosis to steatohepatitis. Furthermore, the treatment also reduced hepatic fibrosis, activated nuclear factor-erythroid-2-related factor-2 which is known to attenuate the progression of NASH-related fibrosis. Interestingly, in fasting mice, a single high-dose SchB induced transient lipolysis and increased the expressions of adipose triglyceride lipase and phospho-hormone sensitive lipase. The treatment also increased plasma cholesterol levels and 3-hydroxy-3-methylglutaryl-CoA reductase activity, reduced the hepatic low-density-lipoprotein receptor expression in these mice. Our data not only suggest SchB is a potential therapeutic agent for NAFLD, but also provided important information for a safe consumption of SchB because SchB overdosed under fasting condition will have adverse effects on lipid metabolism.
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This work was partially supported by GRF grants HKBU262512 and HKBU260613 from Research Grant Council of Hong Kong, FRG2/13-14/016, FRG1/13-14/062, FRG2/12-13/039 and FRG2/13-14/030 from Hong Kong Baptist University, JCYJ20120829154222473 from Shenzhen STIC and No.31071989 from the National Natural Science Foundation of China.
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Kwan, Hiu Yee, Xuyan Niu, Wenlin Dai, Tiejun Tong, Xiaojuan Chao, Tao Su, Chi Leung Chan, Kim Chung Lee, Xiuqiong Fu, Hua Yi, Hua Yu, Ting Li, Anfernee Kai Wing Tse, Wang Fun Fong, Si-Yuan Pan, Aiping Lu, and Zhi-Ling Yu. "Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers." Scientific Reports 5 (2015): 9114.