Department of Chemistry
A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells
Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.
Source Publication Title
Public Library of Science
Link to Publisher's Edition
He, H., Li, D., Yang, L., Fu, L., Zhu, X., Wong, W., Jiang, F., & Liu, Y. (2015). A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells. Scientific Reports (5). https://doi.org/10.1038/srep13543