Department of Chemistry
Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents
The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent. © 2012 Elsevier GmbH. All rights reserved.
Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft
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Lam, K., Lee, K., Gambari, R., Wong, R., Cheng, G., Tong, S., Chan, K., Lau, F., Lai, P., Wong, W., Chan, A., Kok, S., Tang, J., & Chui, C. (2013). Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents. Phytomedicine, 20 (2), 166-171. https://doi.org/10.1016/j.phymed.2012.09.026