Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents
Language
English
Abstract
The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent. © 2012 Elsevier GmbH. All rights reserved.
Keywords
Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft
Publication Date
2013
Source Publication Title
Phytomedicine
Volume
20
Issue
2
Start Page
166
End Page
171
Publisher
Elsevier
DOI
10.1016/j.phymed.2012.09.026
Link to Publisher's Edition
http://dx.doi.org/10.1016/j.phymed.2012.09.026
ISSN (print)
09447113
ISSN (electronic)
1618095X
APA Citation
Lam, K., Lee, K., Gambari, R., Wong, R., Cheng, G., Tong, S., Chan, K., Lau, F., Lai, P., Wong, W., Chan, A., Kok, S., Tang, J., & Chui, C. (2013). Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents. Phytomedicine, 20 (2), 166-171. https://doi.org/10.1016/j.phymed.2012.09.026