Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents
Language
English
Abstract
The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent. © 2012 Elsevier GmbH. All rights reserved.
Keywords
Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft
Publication Date
2013
Source Publication Title
Phytomedicine
Volume
20
Issue
2
Start Page
166
End Page
171
Publisher
Elsevier
DOI
10.1016/j.phymed.2012.09.026
Link to Publisher's Edition
http://dx.doi.org/10.1016/j.phymed.2012.09.026
ISSN (print)
09447113
ISSN (electronic)
1618095X
Recommended Citation
Lam, Kim-Hung, Kenneth Ka-Ho Lee, Roberto Gambari, Raymond Siu-Ming Wong, Gregory Yin-Ming Cheng, See-Wai Tong, Kit-Wah Chan, Fung-Yi Lau, Paul Bo-San Lai, Wai-Yeung Wong, Albert Sun-Chi Chan, Stanton Hon-Lung Kok, Johnny Cheuk-On Tang, and Chung-Hin Chui. "Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents." Phytomedicine 20.2 (2013): 166-171.