Department of Chemistry
Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells
Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl 2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials. © CSIRO 2008.
Source Publication Title
Australian Journal of Chemistry
Link to Publisher's Edition
Lu, G., Ho, C., Wang, Q., Wong, W., Chui, C., Wong, R., Gambari, R., Lau, F., Yuen, M., Tong, C., Chan, A., Tang, J., Ho, K., & Cheng, G. (2008). Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells. Australian Journal of Chemistry, 61 (12), 975-980. https://doi.org/10.1071/CH08342