Department of Chemistry
Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl)porphyrins
A series of (4-cyanophenyl)porphyrins have been prepared and structurally characterized by 1H NMR, IR and UV/Vis spectroscopy, mass spectrometry, and elemental analysis. The relative singlet-oxygen quantum yields, two-photon absorption cross-sections and DNA photocleavage activities of these porphyrins were measured. The results show that (4-cyanophenyl)porphyrins with a properly designed hydrophobic/hydrophilic balance for better cellular uptake have potential application in two-photon-absorption photodynamic therapy. © Wiley-VCH Verlag GmbH & Co. KGaA.
DNA cleavage, Photochemistry, Porphyrinoids, Sensitizers, Singlet oxygen
Source Publication Title
European Journal of Inorganic Chemistry
Link to Publisher's Edition
Wang, K., Poon, C., Wong, W., Wong, W., Choi, C., Kwong, D., Zhang, H., & Li, Z. (2009). Synthesis, characterization, singlet-oxygen photogeneration, DNA photocleavage and two-photon-absorption properties of some (4-cyanophenyl)porphyrins. European Journal of Inorganic Chemistry, 2009 (7), 922-928. https://doi.org/10.1002/ejic.200801047