Department of Chemistry
Synthesis, spectroscopic characterisation and X-ray analysis of regioisomeric 1,3,5-trisubstituted pyrazoles
A new series of regioisomeric 1,3,5-trisubstituted pyrazoles 7-9(a,b) have been synthesized by the reaction of β-diketones (4-6) with methyl hydrazine in ethanol. All the compounds are characterised by the FT-IR, 1H, 13C NMR and mass spectrometry. The crystal structure of compounds 7a, 7b and minor isomer 8b have been determined by X-ray single crystal analysis which showed either of the substituted groups attached to pyrazole ring are essentially non-planar to the central pyrazole ring. Addition of trace amounts of acetic acid during the synthesis of compound 8 resulted in an unexpected compound 10 which is characterised by the X-ray single crystal analysis and is essentially planar. However, crystal structure of 10 is already reported. All structures are further stabilized by the classic and non-classic inter- and intramolecular hydrogen bonding. © 2011 Elsevier B.V. All rights reserved.
β-diketones, Methyl hydrazine, Pyrazoles, X-ray analysis
Source Publication Title
Journal of Molecular Structure
Link to Publisher's Edition
Yunus, U., Kauser, R., Bhatti, M., Zia-Ul-Haq, M., & Wong, W. (2011). Synthesis, spectroscopic characterisation and X-ray analysis of regioisomeric 1,3,5-trisubstituted pyrazoles. Journal of Molecular Structure, 995 (3-1), 173-180. https://doi.org/10.1016/j.molstruc.2011.04.014