Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
A metal-based inhibitor of tumor necrosis factor-α
Language
English
Abstract
Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
inhibitors, iridium(III) complexes, metal-based inhibitors, protein-protein interactions, tumor necrosis factor
Publication Date
2012
Source Publication Title
Angewandte Chemie International Edition
Volume
51
Issue
36
Start Page
9010
End Page
9014
Publisher
Wiley-VCH Verlag
DOI
10.1002/anie.201202937
Link to Publisher's Edition
http://dx.doi.org/10.1002/anie.201202937
ISSN (print)
14337851
ISSN (electronic)
15213773
Recommended Citation
Leung, Chung-Hang, Hai-Jing Zhong, Hui Yang, Zhen Cheng, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma, Ruben Abagyan, Chun-Yuen Wong, and Dik-Lung Ma. "A metal-based inhibitor of tumor necrosis factor-α." Angewandte Chemie International Edition 51.36 (2012): 9010-9014.