Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Bioactive iridium and rhodium complexes as therapeutic agents
Language
English
Abstract
Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded as chemically inert, studies over the past few years have demonstrated that the reactivity and biological activity of iridium and rhodium complexes may be unlocked by a suitable choice of auxiliary ligands. In addition, group 9 metal centers have received increased popularity for the construction of kinetically inert organometallic scaffolds as target-selective protein or enzyme inhibitors. In this review, we summarize the recent strategies that have been utilized for the design and development of bioactive iridium and rhodium complexes. © 2013 Elsevier B.V.
Keywords
Anti-cancer, Inorganic medicine, Iridium, Metallodrug, Rhodium
Publication Date
2013
Source Publication Title
Coordination Chemistry Reviews
Volume
257
Issue
12-11
Start Page
1764
End Page
1776
Publisher
Elsevier
DOI
10.1016/j.ccr.2013.01.034
Link to Publisher's Edition
http://dx.doi.org/10.1016/j.ccr.2013.01.034
ISSN (print)
00108545
Recommended Citation
Leung, Chung-Hang, Hai-Jing Zhong, Daniel Shiu-Hin Chan, and Dik-Lung Ma. "Bioactive iridium and rhodium complexes as therapeutic agents." Coordination Chemistry Reviews 257.12-11 (2013): 1764-1776.