Department of Chemistry
Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic–inorganic hybrid nanocomposites
A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic-inorganic hybrid nanocomposites that contain deferoxamine-coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
gene delivery, imaging agents, magnetofection, nanoparticles, organic-inorganic hybrid composites
Source Publication Title
Chemistry - An Asian Journal
Link to Publisher's Edition
Leung, K., Chak, C., Lee, S., Lai, J., Zhu, X., Wang, Y., Sham, K., Wong, C., & Cheng, C. (2013). Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic–inorganic hybrid nanocomposites. Chemistry - An Asian Journal, 8 (8), 1760-1764. https://doi.org/10.1002/asia.201300202