Department of Chemistry
Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(III) complex
In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.
Amyloid, aggregation, Alzheimer's, luminescent probe, iridium
Source Publication Title
Current Alzheimer Research
Bentham Science Publishers
Link to Publisher's Edition
Wong, Chun-Yuen, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung, and Dik Lung Ma. "Dual inhibition and monitoring of beta-amyloid fibrillation by a luminescent iridium(III) complex." Current Alzheimer Research 12.5 (2015): 439-444.