Department of Chemistry
Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study
In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs. © 2012 Elsevier B.V. All rights reserved.
AOT reverse micelles, Delocalized lipophilic cations, Fluorescence method, Mitochondria
Source Publication Title
Journal of Luminescence
Link to Publisher's Edition
Li, D., Qi, Z., Ding, X., Li, J., Jiang, F., Liu, Y., Kwong, D., & Wong, W. (2013). Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study. Journal of Luminescence, 134, 830-836. https://doi.org/10.1016/j.jlumin.2012.06.041