Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study
Language
English
Abstract
In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs. © 2012 Elsevier B.V. All rights reserved.
Keywords
AOT reverse micelles, Delocalized lipophilic cations, Fluorescence method, Mitochondria
Publication Date
2013
Source Publication Title
Journal of Luminescence
Volume
134
Start Page
830
End Page
836
Publisher
Elsevier
DOI
10.1016/j.jlumin.2012.06.041
Link to Publisher's Edition
http://dx.doi.org/10.1016/j.jlumin.2012.06.041
ISSN (print)
00222313
Recommended Citation
Li, Dong-Wei, Zu-De Qi, Xin-Liang Ding, Jia-Han Li, Feng-Lei Jiang, Yi Liu, Daniel W.J. Kwong, and Wai-Kwok Wong. "Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study." Journal of Luminescence 134 (2013): 830-836.