School of Chinese Medicine
The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria. The bioassay-guided fractionation and separation of the bioactive plant leads resulted in the isolation of approximately 300 compounds of varying degrees of structural complexity and/or biological activity. The present paper summarizes the significant drug discovery achievements made by the UIC-ICBG team of multidisciplinary collaborators in the project over the period of 1998–2012 and the projects carried on in the subsequent years by involving the researchers in Hong Kong.
UIC-ICBG, bioactive compounds, drug discovery, cancer, HIV, tuberculosis, malaria
Source Publication Title
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
The work was supported by the Research Grants Council of the Hong Kong Special Administrative Region (SAR), China (Project No. HKBU12103014 and HKBU12142016), the Health and Medical Research Fund of the Food and Health Bureau (HMRF), Hong Kong SAR, China (12132161), the Hong Kong Baptist University (HKBU) Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/02), Faculty Research Grant, Hong Kong Baptist University (FRG2/15-16/088 and FRG1/15-16/020) and NIH Grants 3U01TW001015-10S1 and 2U01TW001015-11A1 (administered by the Fogarty International Center as part of an International Cooperative Biodiversity Groups program, through funds from NIH, NSF, and Foreign Agricultural Service of the USDA).
Link to Publisher's Edition
Zhang, Hong-Jie, Wan-Fei Li, Harry H. S. Fong, and Djaja Doel Soejarto. "Discovery of bioactive compounds by the UIC-ICBG drug discovery program in the 18 years since 1998." Molecules 21.11 (2016): 1448.