School of Chinese Medicine
There are many herbal teas that are found in nature that may be effective at treating the symptoms and also shortening the duration of viral infections. When combating viral infections, T lymphocytes are an indispensable part of human acquired immunity. However, studies on the use of natural products in stimulating lymphocyte-mediated interferon-gamma (IFN-γ) production are very limited. In this study, we found that acteoside, a natural phenylpropanoid glycoside from Kuding Tea, enhanced IFN-γ production in mouse lymphocytes in a dose-dependent manner, particularly in the CD4+ and CD8+ subsets of T lymphocytes. To this end, we suggest that the antiviral activity of acteoside was highly correlated to its inducing ability of IFN-γ production. Mechanistically, the activation of T-bet enhanced the promoter of IFN-γ and subsequently resulted in an increased IFN-γ production in T cells. Collectively, we have found a natural product with the capacity to selectively enhance mouse T cell IFN-γ production. Given the role of IFN-γ in the immune system, further studies to clarify the role of acteoside in inducing IFN-γ and prevention of viral infection are needed.
Source Publication Title
Food and Function
Royal Society of Chemistry
This journal is © The Royal Society of Chemistry 2016
This study was supported by grants from the Shenzhen Science and Technology Innovation Committee of China, with grant numbers KQCX20140522111508785, CXZZ20150601110000604 and ZDSYS201506031617582; the National Natural Science Foundation of China with grant number 31500285; the Natural Science Foundation of Guangdong Province with grant number 2015A030310529 and the Health and Medical Research Fund (12132161) of the Food and Health Bureau, Hong Kong S.A.R., China.
Link to Publisher's Edition
Song, Xue, Jiang He, Hong Xu, Xiao-Peng Hu, Xu-Li Wu, Hai-Qiang Wu, Li-Zhong Liu, Cheng-Hui Liao, Yong Zeng, Yan Li, Yue Hao, Chen-Shu Xu, Long Fan, Jian Zhang, Hong-Jie Zhang, and Zhen-Dan He. "The antiviral effects of acteoside and the underlying IFN-γ-inducing action." Food and Function 7.7 (2016): 3017-3030.