School of Chinese Medicine
Pectins isolated from Panax ginseng C.A. Meyer are potential therapeutic agents for the treatment of diabetes mellitus, a global health challenge. Soil-to-bench procedures of ginseng pectin preparation significantly affect the polysaccharide structures. Various forms of ginseng pectins rich in homogalacturonan, rhamnogalacturonan-I, rhamnogalacturonan-II, and arabinogalactan have demonstrated independent or collaborative effects on hyperglycemia, oxidative stress, immunological dysfunction, and neoplasms. Monosaccharide compositions, peptide contents, degrees of esterification and methylation, and inter- and intramolecular linkages all influence pectin bioactivity. Understanding the preparation–structure and structure–function relationships of ginseng pectins can lead to safer and more pertinent treatment of diabetes with efficacy-oriented modifications of the pectins. To reach this goal, standardization of preparation procedures, understanding of intricate structures, and exploration of complex interactions with receptors are crucial steps to take full advantage of the medical potential of ginseng pectins.
ginseng pectin, diabetes mellitus, homogalacturonan, rhamnogalacturonan, arabinogalactan
Source Publication Title
Annals of the New York Academy of Sciences
This is the peer reviewed version of the following article: Chen, Q., Zhu, L., Tang, Y., Zhao, Z., Yi, T. and Chen, H. (2017), Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins. Ann. N.Y. Acad. Sci., 1401: 75–89. doi:10.1111/nyas.13424, which has been published in final form at http://dx.doi.org/10.1111/nyas.13424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
This research is funded by National Natural Science Foundation of China, grant numbers: 81603381, 81673691; Guangdong Natural Science Foundation, grant number: 2016A030313008; Shenzhen Science and Technology Innovation Committee, grant number: JCYJ20160518094706544; Faculty Research Grant of Hong Kong Baptist University, grant number: FRG2/15-16/022
Link to Publisher's Edition
Chen, Qilei, Lin Zhu, Yina Tang, Zhongzhen Zhao, Tao Yi, and Hubiao Chen. "Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins." Annals of the New York Academy of Sciences 1401 (2017): 75-89.