School of Chinese Medicine
Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines—particularly natural medicines—work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo, and by decreasing oxidative stress damage. These mechanisms explain the clinical efficacy of DN as an anti-MI drug.
Biotransformation, Intestinal microflora, Cardioprotective effects, Diosgenin, Antioxidant
Source Publication Title
Oxidative Medicine and Cellular Longevity
Article ID 4176518
Hindawi Publishing Corporation
Copyright © 2017 Jia-Fu Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This work was partially supported by the National Natural Science Foundation of China (81603381, 81673691) the Guangdong Natural Science Foundation (2014A030313766, 2016A030313008), the Shenzhen Science and Technology Innovation Committee (JCYJ20160518094706544), and the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022, FRG2/16-17/053).
Link to Publisher's Edition
Feng, J., Tang, Y., Hong, J., Zhu, L., & Yi, T. (2017). Biotransformation of Dioscorea nipponica by rat intestinal microflora and cardioprotective effects of diosgenin. Oxidative Medicine and Cellular Longevity, 2017, Article ID 4176518. https://doi.org/10.1155/2017/4176518