School of Chinese Medicine
Mitochondria play a key role in various cell processes including ATP production, Ca2+ homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.
autophagy, mitophagy, mitochondria, cerebral ischemia
Source Publication Title
© The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
This work was funded by the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022) and the Guandong Natural Science Foundation (2014A030313766 and 2016A030313008).
Link to Publisher's Edition
Tang, Y., Tian, H., Yi, T., & Chen, H. (2016). The critical roles of mitophagy in cerebral ischemia. Protein Cell, 7 (10), 699-713. https://doi.org/10.1007/s13238-016-0307-0