Document Type
Journal Article
Department/Unit
School of Chinese Medicine
Language
English
Abstract
Mitochondria play a key role in various cell processes including ATP production, Ca2+ homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insufficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.
Keywords
autophagy, mitophagy, mitochondria, cerebral ischemia
Publication Date
10-24-2016
Source Publication Title
Protein Cell
Volume
7
Issue
10
Start Page
699
End Page
713
Publisher
Springer Verlag
Peer Reviewed
1
Copyright
© The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Funder
This work was funded by the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022) and the Guandong Natural Science Foundation (2014A030313766 and 2016A030313008).
DOI
10.1007/s13238-016-0307-0
Link to Publisher's Edition
ISSN (print)
1674800X
ISSN (electronic)
16748018
Recommended Citation
Tang, Yan-Cheng, Hong-Xia Tian, Tao Yi, and Hu-Biao Chen. "The critical roles of mitophagy in cerebral ischemia." Protein Cell 7.10 (2016): 699-713.