School of Chinese Medicine
Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.
antibody-drug conjugates (ADCs), targeted therapy, monoclonal antibodies (mAbs), drugs, linkers
Source Publication Title
International Journal of Molecular Sciences
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang) and the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang).
Link to Publisher's Edition
Yao, H., Jiang, F., Lu, A., & Zhang, G. (2016). Methods to design and synthesize antibody-drug conjugates (ADCs). International Journal of Molecular Sciences, 17 (2), 194. https://doi.org/10.3390/ijms17020194