Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from all over the world. In this review, we discuss the different strategies especially prodrug strategies that are currently used to make paclitaxel more effective.

Keywords

paclitaxel, poor water solubility, low selectivity, prodrug

Publication Date

5-2016

Volume

17

Issue

5

Start Page

796

Publisher

MDPI

Peer Reviewed

1

Copyright

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Funder

This study was supported by the Hong Kong General Research Fund (HKBU12102914 to Ge Zhang) and the Faculty Research Grant of Hong Kong Baptist University (FRG2/12-13/027 to Ge Zhang).

DOI

10.3390/ijms17050796

Link to Publisher's Edition

http://dx.doi.org/10.3390/ijms17050796

ISSN (print)

16616596

ISSN (electronic)

14220067

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