School of Chinese Medicine
Osteoporosis is a progressive skeletal disorder characterized by low bone mass and increased risk of fracture in later life. The incidence and costs associated with treating osteoporosis cause heavy socio-economic burden. Currently, the diagnosis of osteoporosis mainly depends on bone mineral density and bone turnover markers. However, these indexes are not sensitive and accurate enough to reflect the osteoporosis progression. Metabolomics offers the potential for a holistic approach for clinical diagnoses and treatment, as well as understanding of the pathological mechanism of osteoporosis. In this review, we firstly describe the study subjects of osteoporosis and bio-sample preparation procedures for different analytic purposes, followed by illustrating the biomarkers with potentially predictive, diagnosis and pharmaceutical values when applied in osteoporosis research. Then, we summarize the published metabolic pathways related to osteoporosis. Furthermore, we discuss the importance of chronological data and combination of multi-omics in fully understanding osteoporosis. The application of metabolomics in osteoporosis could provide researchers the opportunity to gain new insight into the metabolic profiling and pathophysiological mechanisms. However, there is still much to be done to validate the potential biomarkers responsible for the progression of osteoporosis and there are still many details needed to be further elucidated.
osteoporosis, metabolomics, biomarkers, metabolic pathways, chronological data, multi-omics
Source Publication Title
International Journal of Molecular Sciences
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
This study was support by Strategic Development of the School of Chinese Medicine in Research (SDF15-1211-P01).
Link to Publisher's Edition
Lv, H., Jiang, F., Guan, D., Lu, C., Guo, B., Chan, C., Peng, S., Liu, B., Guo, W., Zhu, H., Xu, X., Lu, A., & Zhang, G. (2016). Metabolomics and Its application in the development of discovering biomarkers for osteoporosis research. International Journal of Molecular Sciences, 17 (12), 2018. https://doi.org/10.3390/ijms17122018