Department of Chemistry
Ultrasound, pH, and magnetically responsive crown-ether-coated core/shell nanoparticles as drug encapsulation and release systems
Core@shell nanoparticles with superparamagnetic iron oxide core, mesoporous silica shell, and crown ether periphery were fabricated toward drug delivery and tumor cell imaging. By the concept of nanovalve based on supramolecular gatekeeper, stimuli-responsive drug delivery nanosystems Fe3O 4@SiO2@meso-SiO2@crown ethers were synthesized by (i) modified solvothermal reaction; (ii) sol-gel reaction; and (iii) amide coupling reaction. The successful coupling of the dibenzo-crown ethers onto the mesoporous silica shell was confirmed by thermogravimetric analysis and Infrared spectroscopy. In this system, the "ON/OFF" switching of the gatekeeper supramolecules can be controlled by pH-sensitive intramolecular hydrogen bonding or electrostatic interaction (such as metal chelating). Biological evaluation of the nanoparticles renders them noncytotoxic and can be uptaken by L929 cells. In this work, the antitumor drug (doxorubicin) loading and release profiles which were studied by the UV/visible absorption spectroscopy. The mechanism involves the best-fit binding of crown ethers with cesium or sodium ions at different pH values with ultrasonic wave in phosphate buffered saline (PBS). Magnetic resonance imaging analysis of the particles reveals a high relaxivity, rendering them potentially useful theranostic agents. © 2013 American Chemical Society.
crown ether, drug carrier, magnetic resonance imaging, nanoparticle, ultrasound
Source Publication Title
ACS Applied Materials and Interfaces
American Chemical Society
Link to Publisher's Edition
Lee, Siu-Fung, Xiao-Ming Zhu, Yi-Xiang J. Wang, Shou-Hu Xuan, Qihua You, Wing-Hong Chan, Chi-Hin Wong, Feng Wang, Jimmy C. Yu, Christopher H. K. Cheng, and Ken Cham-Fai Leung. "Ultrasound, pH, and magnetically responsive crown-ether-coated core/shell nanoparticles as drug encapsulation and release systems." ACS Applied Materials and Interfaces 5.5 (2013): 1566-1574.