Department of Chemistry
An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent
An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.
Photodynamic therapy, Porphyroid, Ru(II)-polypyridyl, Tumor-imaging, Two-photon
Source Publication Title
Journal of Inorganic Biochemistry
Link to Publisher's Edition
Poon, C., Chan, P., Man, C., Jiang, F., Wong, R., Mak, N., Kwong, D., Tsao, S., & Wong, W. (2010). An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent. Journal of Inorganic Biochemistry, 104 (1), 62-70. https://doi.org/10.1016/j.jinorgbio.2009.10.004