Document Type

Journal Article

Department/Unit

Research and Development Division, School of Chinese Medicine

Language

English

Abstract

Dioscorea nipponica Makino is a perennial twining herbs belonging to the family Dioscoreaceae, which is mainly distributed in the northeastern, northern, eastern and central regions of China. Traditionally, the rhizome of this herb has been commonly used by Miao and Meng ethnic groups of China to treat rheumatoid arthritis, pain in the legs and lumbar area, Kashin Beck disease, bruises, sprains, chronic bronchitis, cough and asthma. Modern pharmacological studies have discovered that this herb possesses anti-tumor, anti-inflammatory, anti-diuretic, analgesic, anti-tussive, panting-calming and phlegm-dispelling activities, along with enhancing immune function and improving cardiovascular health. In recent years, both fat-soluble and water-soluble steroidal saponins were isolated from the rhizomes of D. nipponica using silica gel column chromatography, thin layer chromatography and high performance liquid chromatography methods. Saponin and sapogenins are mainly responsible for most of the pharmacological effects of this plant. Further, the chemical components of the aboveground parts contain more than 10 kinds of phenanthrene derivatives. The present review summarizes the knowledge concerning the geographical distribution, chemical composition, pharmacological effects, toxicology studies and clinical applications of D. nipponica.

Keywords

Dioscorea nipponica, Makino Steroid saponins, Geographical distribution, Active ingredient, Pharmacological studies

Publication Date

2018

Source Publication Title

Chemistry Central Journal

Volume

12

Issue

1

Start Page

57

Publisher

Springer International Publishing

Peer Reviewed

1

DOI

10.1186/s13065-018-0423-4

Link to Publisher's Edition

https://link.springer.com/article/10.1186/s13065-018-0423-4

ISSN (electronic)

1752-153X

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