Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have played a major role in the management of DM in Asian countries. In particular, mulberry has commonly been utilized in China for the treatment of DM for thousands of years. In the last decade, numerous preclinical findings have suggested that mulberry is a promising therapeutic agent for the treatment of DM, and the polyhydroxylated alkaloids, flavonoids and polysaccharides from mulberry may be the potential active components. The present review systematically summarizes the chemical composition of mulberry and the pharmacological effects of different medicinal parts on DM; these effects include influences on glucose absorption, insulin (INS) production/secretion, anti-oxidation and anti-inflammation processes. After summarizing our research findings, we will discuss the challenges and opportunities and explore the direction of future research and the potential for developing mulberry into pharmaceuticals for the widespread treatment of DM.

Keywords

Diabetes Mellitus, Medicinal Potential, Polyhydroxylated Alkaloids, Review

Publication Date

12-2018

Source Publication Title

The American Journal of Chinese Medicine

Volume

46

Issue

8

Start Page

1743

End Page

1770

Publisher

World Scientific Publishing

DOI

10.1142/S0192415X1850088X

Link to Publisher's Edition

https://doi.org/10.1142/S0192415X1850088X

ISSN (print)

0192415X

ISSN (electronic)

17936853

Available for download on Thursday, December 05, 2019

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