Document Type

Journal Article

Department/Unit

School of Chinese Medicine

Language

English

Abstract

A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki–Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Furthermore, a parallel synthesis of biaryl analogs is accomplished at room temperature using the strategy, which enhances the practical usefulness of this method.

Keywords

Palladium-catalyzed borylation, Aryl (pseudo)halides, Suzuki–Miyaura cross coupling, Biaryl synthesis

Publication Date

2018

Source Publication Title

Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis

Volume

12

Issue

123

Publisher

SpringerOpen

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

DOI

10.1186/s13065-018-0510-6

Link to Publisher's Edition

https://doi.org/10.1186/s13065-018-0510-6

ISSN (electronic)

1752153X

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