School of Chinese Medicine
A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki–Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Furthermore, a parallel synthesis of biaryl analogs is accomplished at room temperature using the strategy, which enhances the practical usefulness of this method.
Palladium-catalyzed borylation, Aryl (pseudo)halides, Suzuki–Miyaura cross coupling, Biaryl synthesis
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Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis
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Ji, H., Cai, J., Gan, N., Wang, Z., Wu, L., Li, G., & Yi, T. (2018). Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis. Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis, 12 (123). https://doi.org/10.1186/s13065-018-0510-6