Document Type

Journal Article

Department/Unit

Department of Chemistry

Language

English

Abstract

Increasing prevalence of childhood obesity poses threats to the global health burden. Because this rising prevalence cannot be fully explained by traditional risk factors such as unhealthy diet and physical inactivity, early-life exposure to endocrine disrupting chemicals (EDCs) is recognized as emerging novel risk factors for childhood obesity. EDCs can disrupt the hormone-mediated metabolic pathways, affect children’s growth and mediate the development of childhood obesity. Many organic pollutants are recently classified to be EDCs. In this review, we summarized the epidemiological and laboratory evidence related to EDCs and childhood obesity, and discussed the possible mechanisms underpinning childhood obesity and early-life exposure to non-persistent organic pollutants (phthalates, bisphenol A, triclosan) and persistent organic pollutants (dichlorodiphenyltrichloroethane, polychlorinated biphenyls, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances). Understanding the relationship between EDCs and childhood obesity helps to raise public awareness and formulate public health policy to protect the youth from exposure to the harmful effects of EDCs.

Keywords

Endocrine disrupting chemicals, Childhood obesity, Persistent organic pollutants, Early-life exposure

Publication Date

2018

Source Publication Title

Annals of Pediatric Endocrinology & Metabolism

Volume

23

Issue

4

Start Page

182

End Page

195

Publisher

Korean Society of Pediatric Endocrinology

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

DOI

10.6065/apem.2018.23.4.182

Link to Publisher's Edition

https://doi.org/10.6065/apem.2018.23.4.182

ISSN (print)

22871012

ISSN (electronic)

22871292

Included in

Chemistry Commons

Share

COinS