HKBU Institutional Repository

Document Type

Journal Article

Authors

Wenyu Liu, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Yanqiu Zhou, State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
Jiufeng Li, State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
Xiaojie Sun, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Hongxiu Liu, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Yanqian Jiang, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Yang Peng, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Hongzhi Zhao, State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
Wei Xia, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Yuanyuan Li, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Zongwei Cai, State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong
Shunqing Xu, Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Department/Unit

Department of Chemistry

Title

Parabens exposure in early pregnancy and gestational diabetes mellitus

Language

English

Abstract

Abstract

Background

Widespread exposure to parabens has been a concern, especially among pregnant women. Only one study reported that parabens are associated with glucose levels among pregnant women. However, studies on parabens exposure and gestational diabetes mellitus (GDM) are lacking.

Objectives

This study investigated whether exposure to parabens in early pregnancy is related to GDM.

Methods

We conducted a prospective study of 1087 pregnant women from a single tertiary medical center between 2014 and 2015 in Wuhan, China. Parabens [methyl paraben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP), and benzylparaben (BzP)] concentrations were measured in spot urine samples collected between 8 and 16 gestational weeks. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups Consensus Panel (IADPSG) recommendations. We used the Poisson regression with a robust error variance with generalized estimating equations (GEE) estimation analyses to evaluate associations between parabens exposure and GDM risk.

Results

A total of 103 (9.5%) women were diagnosed with GDM. We evaluated the associations of GDM risk with urinary MeP, EtP, and PrP (detection rate: >90%), but not with BuP and BzP due to the relatively low detection rate (<50%). After adjustment for potential confounders, urinary EtP was associated with GDM. The risk ratios (RRs) = 1.12 (95% CI: 0.63, 2.01) for the second quartile, RRs = 1.11 (95% CI: 0.64, 1.93) for the third quartile, and RRs = 1.70 (95% CI: 1.02, 2.82) for the highest quartile, compared with the lowest quartile. There was no evidence of associations between urinary MeP or PrP and GDM.

Conclusions

To the best of our knowledge, this is the first report of an association between urinary paraben levels in early pregnancy and GDM. Our findings suggest that exposure to EtP may increase the risk of GDM.

Keywords

Gestational diabetes mellitus, Parabens, Prospective cohort study

Publication Date

5-2019

Source Publication Title

Environment International

Volume

126

Start Page

468

End Page

475

Publisher

Elsevier

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

DOI

10.1016/j.envint.2019.02.040

Link to Publisher's Edition

http://dx.doi.org/10.1016/j.envint.2019.02.040

ISSN (print)

01604120

ISSN (electronic)

18736750

APA Citation

Liu, W., Zhou, Y., Li, J., Sun, X., Liu, H., Jiang, Y., Peng, Y., Zhao, H., Xia, W., Li, Y., Cai, Z., & Xu, S. (2019). Parabens exposure in early pregnancy and gestational diabetes mellitus. Environment International, 126, 468-475. https://doi.org/10.1016/j.envint.2019.02.040