Department of Chemistry
Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2
Iron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. © 2009 Elsevier Inc. All rights reserved.
Anti-proliferation, Apoptosis, Caco2 cell, Desferrioxamine, Mitochondria
Source Publication Title
Journal of Inorganic Biochemistry
Link to Publisher's Edition
Sun, X., Ge, R., Cai, Z., Sun, H., & He, Q. (2009). Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. Journal of Inorganic Biochemistry, 103 (7), 1074-1081. https://doi.org/10.1016/j.jinorgbio.2009.05.004