School of Chinese Medicine
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have abilities to bind to specific target molecules that rival those of monoclonal antibodies. They are attracting great attention in diverse clinical translations on account of their various advantages, including prolonged storage life, little batch-to-batch differences, very low immunogenicity, and feasibility of chemical modifications for enhancing stability, prolonging the half-life in serum, and targeted delivery. In this Review, we demonstrate the emerging aptamer discovery technologies in developing advanced techniques for producing aptamers with high performance consistently and efficiently as well as requiring less cost and resources but offering a great chance of success. Further, the diverse modifications of aptamers for therapeutic applications including therapeutic agents, aptamer–drug conjugates, and targeted delivery materials are comprehensively summarized.
aptamer, microfluidic SELEX, long-acting modification, aptamer−drug conjugate (ApDC), targeted delivery materials, nanoparticle, therapeutic application
Source Publication Title
Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications
American Chemical Society
Link to Publisher's Edition
Ni, S., Zhuo, Z., Pan, Y., Yu, Y., Li, F., Liu, J., Wang, L., Wu, X., Li, D., Wan, Y., Zhang, L., Yang, Z., Zhang, B., Lu, A., & Zhang, G. (2020). Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications. Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications. https://doi.org/10.1021/acsami.0c05750