Document Type
Journal Article
Department/Unit
Department of Chemistry
Title
Structure-based discovery of natural-product-like TNF-α inhibitors
Language
English
Abstract
(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Keywords
Drug discovery, Inhibitors, Natural products, Tumor necrosis factor, Virtual screening
Publication Date
2010
Source Publication Title
Angewandte Chemie International Edition
Volume
49
Issue
16
Start Page
2860
End Page
2864
Publisher
Wiley-VCH Verlag
DOI
10.1002/anie.200907360
Link to Publisher's Edition
http://dx.doi.org/10.1002/anie.200907360
ISSN (print)
14337851
ISSN (electronic)
15213773
Recommended Citation
Chan, Daniel Shiu-Hin, Ho-Man Lee, Fang Yang, Chi-Ming Che, Catherine C. L. Wong, Ruben Abagyan, Chung-Hang Leung, and Ma. Dik-Lung. "Structure-based discovery of natural-product-like TNF-α inhibitors." Angewandte Chemie International Edition 49.16 (2010): 2860-2864.