Department of Chemistry
A natural product-like inhibitor of NEDD8-activating enzyme
The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range. © 2011 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Leung, C., Chan, D., Yang, H., Abagyan, R., Lee, S., Zhu, G., Fong, W., & Ma, D. (2011). A natural product-like inhibitor of NEDD8-activating enzyme. Chemical Communications, 47 (9), 2511-2513. https://doi.org/10.1039/C0CC04927A