Department of Chemistry
A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion
A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(iii) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(iii) probe. The assay is simple and highly selective. © 2012 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
He, H., Chan, D., Leung, C., & Ma, D. (2012). A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion. Chemical Communications, 48 (76), 9462-9464. https://doi.org/10.1039/C2CC32253F