Department of Chemistry
An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification
A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme. © 2011 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Lin, Z., Yang, W., Zhang, G., Liu, Q., Qiu, B., Cai, Z., & Chen, G. (2011). An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification. Chemical Communications, 47 (32), 9096-9071. https://doi.org/10.1039/c1cc13146j