Department of Chemistry
An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification
A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme. © 2011 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Lin, Zhenyu, Weiqiang Yang, Guiyun Zhang, Qida Liu, Bin Qiu, Zongwei Cai, and Guonan Chen. "An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification." Chemical Communications 47.32 (2011): 9096-9071.