Department of Chemistry
Chiral sulfonimide as a brønsted acid organocatalyst for asymmetric friedel–crafts alkylation of indoles with imines
Binaphthyl-based chiral sulfonimide (CSI) is demonstrated for the first time to be an efficient, strong Brønsted acid in asymmetric organocatalysis. A series of CSIs were synthesized and screened in the asymmetric Friedel-Crafts alkylation of indoles with imines. Good to excellent yields and enantioselectivities have been achieved. It was proved that it was crucial to wash the CSI catalyst with HCl before use. © 2011 American Chemical Society.
Source Publication Title
Journal of Organic Chemistry
American Chemical Society
Link to Publisher's Edition
Chen, L., He, H., Chan, W., & Lee, A. (2011). Chiral sulfonimide as a brønsted acid organocatalyst for asymmetric friedel–crafts alkylation of indoles with imines. Journal of Organic Chemistry, 76 (17), 7141-7147. https://doi.org/10.1021/jo2011335