Department of Chemistry
Effect of Surface-functionalized Nanoparticles on the Elongation Phase of Beta-amyloid (l-40) Fibrillogenesis
The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ 1-40 peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ 1-40 fibrillogenesis © 2012 Elsevier Ltd.
Nanoparticle, Peptide, Self-assembly, Surface modification
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Link to Publisher's Edition
Chan, H., Xiao, L., Yeung, K., Ho, S., Zhao, D., Chan, W., & Li, H. (2012). Effect of Surface-functionalized Nanoparticles on the Elongation Phase of Beta-amyloid (l-40) Fibrillogenesis. Biomaterials, 33 (18), 4443-4450. https://doi.org/10.1016/j.biomaterials.2012.03.024