Department of Chemistry
Inhibition of Janus kinase 2 by cyclometalated rhodium complexes
Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2. © 2012 The Royal Society of Chemistry.
Source Publication Title
Royal Society of Chemistry
Link to Publisher's Edition
Leung, C., Yang, H., Ma, V., Chan, D., Zhong, H., Li, Y., Fong, W., & Ma, D. (2012). Inhibition of Janus kinase 2 by cyclometalated rhodium complexes. MedChemComm, 3 (6), 696-698. https://doi.org/10.1039/C2MD00306F