This study is based on the announcement by Dr. He Jiankui of Southern University of Science and Technology on November 26, 2018 that a pair of gene-edited babies were born in China in November. It discusses the ethical problems posed by Dr. He's research in CRISPR-based gene editing technology for human embryos, analyzes the scientific and ethical problems in CRISPR/Cas9 technology and choosing CCR5 as the target of anti-AIDS infection, and investigates the feasibility of relevant research. The fact that human genetic material can be irreversibly transformed into a human gene pool presents a huge risk and an ethical controversy. Therefore, we should strengthen the regulation and supervision of gene editing research at this stage. In this immature phase of technology development, we cannot conduct gene editing research with human germ cells and human embryos at will, especially clinical research.