Modern biotechnology that creates living organisms challenge the traditional definition of life. This paper argues that although we should be very cautious when using synthetic biology, it would be ethically wrong and practically unwise to resist the new biotechnology all together. Daoism is used to discuss the dilemma between being natural (ziran) and being artificial (renwei). Moreover, Daoism calls for the Chinese science community to develop an ethical-regulatory framework to deal with both the potential of biotechnological research and its risks. The paper urges that if we decide to proceed with biotechnology, relevant factors concerning bio-safety and bio-security must be addressed immediately in China.