School of Chinese Medicine
In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.
Science and Technology of Advanced Materials
National Institute for Materials Science
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Iridium(III) complex, chemosensor, thiols
Mao, Zhifeng, Jinbiao Liu, Tian-Shu Kang, Wanhe Wang, Quanbin Han, Chun-Ming Wang, Chung-Hang Leung, and Dik Lung Ma. "An Ir(III) complex chemosensor for the detection of thiols." Science and Technology of Advanced Materials 17.1 (2016): 109-114.