School of Chinese Medicine
In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.
Iridium(III) complex, chemosensor, thiols
Source Publication Title
Science and Technology of Advanced Materials
National Institute for Materials Science
Link to Publisher's Edition
Mao, Zhifeng, Jinbiao Liu, Tian-Shu Kang, Wanhe Wang, Quanbin Han, Chun-Ming Wang, Chung-Hang Leung, and Dik Lung Ma. "An Ir(III) complex chemosensor for the detection of thiols." Science and Technology of Advanced Materials 17.1 (2016): 109-114.