Document Type
Journal Article
Department/Unit
School of Chinese Medicine
Language
English
Abstract
Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson’s disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. In addition, the neuroprotective effect of TGY was also evaluated in the human dopaminergic neuroblastoma SH-SY5Y cell line treated with rotenone and the rotenone intoxicated hemi-parkinsonian rats. In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. Conclusively, TGY is neuroprotective in PD models both in vivo and in vitro.
Publication Date
11-30-2015
Source Publication Title
Scientific Reports
Volume
5
Start Page
16862
Publisher
Nature Publishing Group
Peer Reviewed
1
DOI
10.1038/srep16862
Link to Publisher's Edition
http://dx.doi.org/10.1038/srep16862
ISSN (print)
20452322
APA Citation
Liu, L., Song, J., Lu, J., Huang, Y., Zeng, Y., Chen, L., Durairajan, S., Han, Q., & Li, M. (2015). Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease. Scientific Reports, 5 (). https://doi.org/10.1038/srep16862