School of Chinese Medicine
Palladium/silver-cocatalyzed tandem reactions of oxabenzonorbornadienes with substituted arylacetylenes: A simple method for the preparation of 1,2-diarylethanones and 1,2-diarylacetylenes
The effective synthesis of 1,2-diarylethanones was achieved using palladium(II) acetate [Pd(OAc)2] and silver triflate (AgOTf) as cocatalysts from various oxabenzonorbornadiene derivatives and substituted arylacetylenes via tandem reactions under mild conditions. Exploration of the oxabenzonorbornadiene substrates showed that the 1,2-diarylacetylenes were obtained from adjacent alkoxy substituted oxabenzonorbornadiene derivatives. Preliminary mechanistic studies indicate that the AgOTf served as an indispensable catalyst, and the mechanism of the tandem reaction was proposed.
Source Publication Title
American Chemical Society
Link to Publisher's Edition
Chen, Jingchao, Shanshan Liu, Yongyun Zhou, Sifeng Li, Chengyuan Lin, Zhaoxiang Bian, and Baomin Fan. "Palladium/silver-cocatalyzed tandem reactions of oxabenzonorbornadienes with substituted arylacetylenes: A simple method for the preparation of 1,2-diarylethanones and 1,2-diarylacetylenes." Organometallics 34.17 (2015): 4318-4322.